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106 results

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Page 1
Showing results for lrr and skin
Search for BLTR and Skin instead (1 results)
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. Robinson KS, et al. Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14. Science. 2022. PMID: 35857590 Free PMC article.
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. ...Moreover, fusing NLRP1(DR) to CARD8, which is insensitive to RSR by itself, creates a minimal inflammasome sensor f …
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin a …
Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea.
Deng Z, Chen M, Zhao Z, Xiao W, Liu T, Peng Q, Wu Z, Xu S, Shi W, Jian D, Wang B, Liu F, Tang Y, Huang Y, Zhang Y, Wang Q, Sun L, Xie H, Zhang G, Li J. Deng Z, et al. Nat Commun. 2023 Jul 5;14(1):3958. doi: 10.1038/s41467-023-39761-2. Nat Commun. 2023. PMID: 37402769 Free PMC article.
Rosacea is a chronic inflammatory skin disorder with high incidence rate. Although genetic predisposition to rosacea is suggested by existing evidence, the genetic basis remains largely unknown. ...In a mouse model recapitulating a recurrent Lrrc4 mutation from human patie …
Rosacea is a chronic inflammatory skin disorder with high incidence rate. Although genetic predisposition to rosacea is suggested by …
Locoregional recurrence in skin-sparing and nipple-sparing mastectomies.
Costeira B, da Silva FB, Oom R, Costa C, Moniz JV, Abecasis N, Santos CR. Costeira B, et al. J Surg Oncol. 2022 Mar;125(3):352-360. doi: 10.1002/jso.26725. Epub 2021 Oct 23. J Surg Oncol. 2022. PMID: 34687468
The primary outcome was LRR. Secondary outcomes included LRR predictive factors, overall survival (OS), and disease-free survival (DFS). ...The associated LRR rate is 3.0%, with risk factors being high grade, negative estrogen receptor status, and high Ki67.. …
The primary outcome was LRR. Secondary outcomes included LRR predictive factors, overall survival (OS), and disease-free survi …
Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites.
Díaz-Balzac CA, Rahman M, Lázaro-Peña MI, Martin Hernandez LA, Salzberg Y, Aguirre-Chen C, Kaprielian Z, Bülow HE. Díaz-Balzac CA, et al. Curr Biol. 2016 Sep 12;26(17):2379-87. doi: 10.1016/j.cub.2016.07.008. Epub 2016 Jul 21. Curr Biol. 2016. PMID: 27451901 Free PMC article.
Yet, only a few non-cell-autonomously acting proteins have been identified, including semaphorins [4, 5], brain-derived neurotrophic factors (BDNFs) [6], UNC-6/Netrin [7], and the conserved MNR-1/Menorin-SAX-7/L1CAM cell adhesion complex [8, 9]. This complex acts from the skin …
Yet, only a few non-cell-autonomously acting proteins have been identified, including semaphorins [4, 5], brain-derived neurotrophic factors …
Racial and Ethnic Disparities in Locoregional Recurrence Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer: A Post Hoc Analysis of the TAILORx Randomized Clinical Trial.
Kantor O, King TA, Freedman RA, Mayer EL, Chavez-MacGregor M, Korde LA, Sparano JA, Mittendorf EA. Kantor O, et al. JAMA Surg. 2023 Jun 1;158(6):583-591. doi: 10.1001/jamasurg.2023.0297. JAMA Surg. 2023. PMID: 37043210 Free PMC article.
CONCLUSIONS AND RELEVANCE: In this post hoc analysis, racial and ethnic differences in LRR were observed among patients with T1-2N0 HR-positive, ERBB2-negative breast cancer despite high rates of treatment receipt in this clinical trial population, with the highest LRR …
CONCLUSIONS AND RELEVANCE: In this post hoc analysis, racial and ethnic differences in LRR were observed among patients with T1-2N0 H …
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify.
Sebastião AI, Ferreira I, Brites G, Silva A, Neves BM, Teresa Cruz M. Sebastião AI, et al. Pharmaceutics. 2020 Sep 11;12(9):867. doi: 10.3390/pharmaceutics12090867. Pharmaceutics. 2020. PMID: 32933004 Free PMC article. Review.
However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we sought to discuss the molecular mechanisms underlying DAMPs release and NLRP3 inflammasome activation triggered by skin allergens. The el …
However, skin allergens-danger signals-NLRP3 inflammasome axis is yet to be completely elucidated. Therefore, in this review, we soug …
Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition.
Wang Y, Jing L, Lei X, Ma Z, Li B, Shi Y, Zhang W, Li Y, Zhou H, Hu K, Xue Y, Jin Y. Wang Y, et al. Stem Cell Res Ther. 2023 Sep 19;14(1):257. doi: 10.1186/s13287-023-03490-6. Stem Cell Res Ther. 2023. PMID: 37726853 Free PMC article.
BACKGROUND: Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR …
BACKGROUND: Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which c …
Radiotherapy after skin-sparing mastectomy with immediate breast reconstruction in intermediate-risk breast cancer : Indication and technical considerations.
Hehr T, Baumann R, Budach W, Duma MN, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Krug D, Piroth MD, Sedlmayer F, Souchon R, Wenz F, Sauer R; Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO). Hehr T, et al. Strahlenther Onkol. 2019 Nov;195(11):949-963. doi: 10.1007/s00066-019-01507-9. Epub 2019 Aug 26. Strahlenther Onkol. 2019. PMID: 31451835 Review. English.
BACKGROUND: Skin-sparing (SSME) and nipple-sparing mastectomy (NSME) were developed to improve the cosmetic results for breast cancer (BC) patients, both allowing for immediate breast reconstruction. ...The impact of adequate systemic treatment and the value of radiotherap …
BACKGROUND: Skin-sparing (SSME) and nipple-sparing mastectomy (NSME) were developed to improve the cosmetic results for breast cancer …
Factors Predicting Locoregional Recurrence After Neoadjuvant Chemotherapy and Nipple-Sparing/Skin-Sparing Mastectomy With Immediate Breast Reconstruction.
Wu ZY, Kim HJ, Lee JW, Chung IY, Kim J, Lee SB, Son BH, Eom JS, Jeong JH, Gong G, Kim HH, Ahn SH, Ko B. Wu ZY, et al. Front Oncol. 2021 Jul 1;11:675955. doi: 10.3389/fonc.2021.675955. eCollection 2021. Front Oncol. 2021. PMID: 34277421 Free PMC article.
Herein, we evaluated the factors predicting LRR in a large series of patients who underwent either nipple- (NSM) or skin-sparing mastectomy (SSM) with IBR after NACT. ...RESULTS: During a median follow-up of 63 months, LRR as the first event occurred in 73 pa …
Herein, we evaluated the factors predicting LRR in a large series of patients who underwent either nipple- (NSM) or skin-spari …
IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway.
Cho KA, Suh JW, Lee KH, Kang JL, Woo SY. Cho KA, et al. Int Immunol. 2012 Mar;24(3):147-58. doi: 10.1093/intimm/dxr110. Epub 2011 Dec 29. Int Immunol. 2012. PMID: 22207130
BACKGROUND: The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, and one of these, IL-1beta, has been previously implicated in inflammatory skin disease. ...Additionally, skin inflammation induced by the drug imi …
BACKGROUND: The pathogenesis of inflammatory skin disease involves the release of cytokines from keratinocytes, and one of these, IL- …
106 results